Schizophrenic spectrum disorders are a category of mental disorders that includes schizophrenia and other types of psychotic disorders. These are diseases of chronic and progressive course that usually require lifelong treatment and the taking of psychopharmaceuticals. According to various studies, the life expectancy of these patients is as much as 10 – 30 years shorter than the general population. Physical illnesses contribute to about 60% of premature deaths in patients with schizophrenia. Unhealthy lifestyles, poor eating habits, lack of physical activity, smoking, alcohol abuse and other psychoactive substances are all risk factors in these patients that adversely affect their physical health. In addition, there is still a stigma carried by mental illness, and in particular schizophrenia, making it difficult to access health care and provide adequate health care. Psychopharmacotherapy and polypragmasia in these patients is also a risk factor for body comorbidities due to potential drug interactions as well as their side effects in the form of metabolic syndrome which is a risk factor for diabetes, hypertension, cardiovascular and cerebrovascular diseases. Smoking in patients with schizophrenia or psychosis is 2-4 times more likely than in the general population and increases the risk of mortality more than twice due to the impact on the cardiovascular and respiratory systems. To improve the physical health of patients with schizophrenia, early prevention, lifestyle interventions, rational use of psychopharmaceuticals and management of physical comorbidities at the very beginning and first contact with the mental health service and integrated care of physical and mental disorders as a priority in the provision of health care are necessary.