Introduction: The cardiopulmonary resuscitation (CPR) is one of the most demanding and stressful procedures inside and outside the hospital. Nursing, as an indispensable component of the medical team in basic and advanced resuscitation procedures, is exposed to the severity of the accompanying stress of resuscitation. An individual's response to stress is subjective and individual. It is most often accompanied by a series of emotional and somatic reactions resulting from the complexity of the event itself and the length and frequency of exposure to CPR. Aim of the research: To determine the frequency of exposure of nursing students to cardiopulmonary resuscitation, as well as the intensity of the experienced stress and the factors that contribute to its occurrence. Subjects and research methods: The study was conducted among 104 healthcare professionals (nurses and technicians from inside and outside the hospital) who were divided into two groups: Group I = with multiple experience in CPR (CPR≥1) and Group BI = with first experience in CPR (CPR=1). The survey questionnaire was administered via the online interface "Google Forms", and the results of the statistical analysis were expressed numerically in the form of absolute numbers (n) and frequencies (%) and presented in tables with median and interquartile range. The presence of differences was examined using the Chi-square test or Fisher's exact test and the Mann-Whitney U test or Kruskal-Wallis test. Results: After conducting the research, the results can be divided into five groups, namely results related to the sociodemographic characteristics of the respondents, general parameters of stress intensity assessment, objective factors during CPR performance, subjective factors during CPR performance, and the impact of CPR education on stress reduction. The respondents from Group BI were younger (70% of them under 30 years of age, P<0.0001) and had mostly up to 5 years of work experience (34%), unlike Group I, which had an equal number of respondents of young age (40%) and middle age (40%) and where as many as 30% of the respondents had work experience longer than 16 years. Also, significantly more respondents with experience believed that stress did not affect their actions during resuscitation (83%) compared to respondents without experience who were convinced that stress significantly affected their work (77%) (χ2=0.57; P=0.0001). Respondents from both groups believed that the combination of external and internal (i.e. personal) factors contributed most to the increase in stress during CPR, and they cited resuscitation of a young person or child as the strongest personal factor contributing to the increase in stress intensity. Also, respondents with experience were significantly more likely to feel calm, without changes in their work during participation in CPR (57% Group I; P=0.035), while respondents with one experience in resuscitation also felt a rapid heartbeat, sweating, and headache (32% Group BI; P=0.4457), which occurred as a result of their insecurity and lack of self-confidence. Both groups considered that the organization of additional education on cardiopulmonary resuscitation would contribute to the reduction of stress during their participation in the procedure itself, as well as the constant availability of a professional with whom they could talk openly. Conclusion: Cardiopulmonary resuscitation (CPR) represents one of the most stressful events for healthcare personnel. Nurses and technicians with many years of work experience at workplaces where they often encounter the procedure of cardiopulmonary resuscitation are much better at handling the tasks and challenges that performing CPR puts before them due to the acquired knowledge and years of experience in clinical practice, and thus, they are better they also deal with stress and its consequences, unlike health personnel who do not have enough experience in clinical practice.