Introduction: There are three different types of anesthesia that can be applied: local (operations limited to a small, superficial region of the body), regional and general anesthesia (operations on the trunk, heart, blood vessels) and similar.). General anesthesia leads to a reversible loss of consciousness and loss of pain in the entire organism so that demanding surgical procedures can be performed. Regional anesthesia is an anesthesia technique in which, with the help of a local anesthetic, the surrounding area of the nerve or nerve bundle is blocked, resulting in insensitivity (ie, numbness) or anesthesia of the part of the body in the innervation area of the blocked nerve, which enables a painless surgical procedure. Objective: To determine the attitude of patients towards general and regional anesthesia in those without previous experience and those with anesthesia experience, and to try to determine the reasons for their attitude. Subjects and methods: In the prospective study, an anonymous questionnaire was used, which randomly selected 116 adult subjects of both sexes. The subjects were divided into group A (without anesthesia experience) and group B (with anesthesia experience). Quantitative data expressed with mean value and standard deviation, and qualitative data with frequency in percentage. The collected data are presented graphically and in tables. The χ2 test was used to compare the results. The significance of the difference in the comparison of the results of the examined groups was accepted at p<0.05. Results: A significantly higher percentage of patients with no experience with anesthesia still opted for general anesthesia (67% vs regional 34%). According to the acquired experience in anesthesia, there is no longer any significant difference in the selection of respondents for general (67% vs 56%; p=0.1099) and regional anesthesia (34% vs 44%; p=0.1471). Significantly, the most frequent number of respondents would repeat the choice of general anesthesia on the recommendation of a doctor (without 50% vs with experience 49%; p<0.001). Expected unpleasant experience with spinal/epidural anesthesia was significantly lower in patients after they gained experience with anesthesia (30% vs no experience 57%; p=0.0001). It is interesting to note that a conversation with an anesthesiologist, among subjects with experience in anesthesia, did not influence a major change in their opinion about general or regional anesthesia (64% vs no experience 57%; p=0.0701) Conclusion: It is concluded that respondents without experience in anesthesia prefer general over regional anesthesia, while those with experience equally opt for general and regional anesthesia. The fear of waking up in the middle of the operation (general anesthesia) or the fear that patients will still feel pain during the operation (regional anesthesia) stand out as the main reasons for the respondents' choice of one of these two types of anesthesia.