The goal of this paper is to investigate the occurrence of depressive symptoms in patients with angina pectoris and post myocardial infarction, the association of these symptoms with prognosis of disease and quality of life. For the purpose of this study, 40 subjects were examined: 10 with angina pectoris and 10 with myocardial infarction at cardiology department, and the other 20 were control group without these diseases. Depression is a disorder that characterizes the negative emotional state of a diseased individual. They mark different symptoms, such as feeling sad, helplessness, guilt, restlessness, mood changes and suicidalness. According to research, it affects women's population more and more, is one of the most common mental illnesses of the day. The number of people with depression is on the rise, while the onset of the disease is moving more and more to the younger age. It most often occurs as a reaction to some life events, and its symptoms may range from mild bouts of sadness to severe disturbances. Disease contributes to endangering the functioning of people in daily activities, and thus the disruption of social relations. It has been observed that cardiac patients have a significantly higher risk of depression or some of its symptoms. The results show more pronounced depressive symptoms in patients with angina pectoris or myocardial infarction compared to a control group of patients who were not exposed to these diseases. It has also been noted that patients with angina pectoris have an intermittent appearance of some depressed symptoms than those with prematurely inflamed myocardial infarction such as depression, slow-motion or agitation.